Source: http://www.thehollywoodgossip.com/2013/04/the-internship-trailer-released/
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Friday, April 19, 2013
Thursday, April 18, 2013
'First step' in addressing effects of climate change
Apr. 18, 2013 ? A new report on the potential effects of climate change on NOAA's Olympic Coast National Marine Sanctuary uses existing observations and science-based expectations to identify how climate change could affect habitats, plants and animals within the sanctuary and adjacent coastal areas.
It also outlines new management recommendations for the sanctuary, and sanctuary officials called it the first step toward addressing them.
They also said the report issued by the sanctuary, Climate Change and the Olympic Coast National Marine Sanctuary: Interpreting Potential Futures, will provide a foundation of information and identify key issues facing the sanctuary.
"Climate change poses an increasingly grave threat to the health of the ocean, and its impacts will be felt in marine protected areas like the Olympic Coast sanctuary," said Carol Bernthal, sanctuary superintendent. "This report begins our work to develop management strategies that will help us anticipate potential challenges and adapt to the changing marine environment through sound science, public outreach, and partnerships."
According to the report, climate change could affect the sanctuary through increases in sea level; extreme weather events such as winds, waves, and storms; and coastal erosion from those events. The report also says the region may experience an increase in ocean acidity and water temperature, as well as more extreme weather patterns, including Pacific Northwest regional rainfall increases triggering 100-year magnitude floods.
Prepared and edited by Washington Sea Grant and sanctuary staff, the new climate report is the outcome of more than a year of intensive collaboration among subject matter experts representing 27 agencies, organizations and academic institutions.
The authors also made recommendations for future action for sanctuary management, including focus on public education, information gathering, and policy and management strategies. Scientists, educators, natural resource managers, and communicators will continue to work together to outline regional next steps forward.
Report: http://sanctuaries.noaa.gov/science/conservation/cc_ocnms.html
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/MIF9vm7S2zo/130418154417.htm
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French execs accused of breast implant swindle
MARSEILLE, France (AP) ? The computer records were scrubbed, inspectors said there was no mention of industrial silicone in quality-control documents, and an employee at the factory in southern France said they were instructed not to ask too many questions about the breast implants sold worldwide.
As a fraud trial opened Wednesday, hundreds of women who crowded into a makeshift courtroom were not the only ones claiming they were cheated by Poly Implant Prothese, which is accused of using cheap silicone to fill tens of thousands of implants that were prone to ruptures and leaking.
A former employee and the company that cleared PIP for certification said in interviews outside the court that they too were victims of the five former PIP executives on trial, and offered a glimpse into what they said was a years-long deception.
Jean-Claude Mas, who founded and ran the now-defunct company, is among those facing trial in the southern city of Marseille on charges of fraud and swindling. The company had claimed its factory in France exported to more than 60 countries and was one of the world's leading implant makers.
The implants were not available in the United States, but more than 125,000 women worldwide received them until sales ended in March 2010. Of those, more than 5,000 are joining the trial, saying the executives misled them into believing the silicone gel implants were safe.
Mas' lawyers said the number of women listed in the case as victims is the largest in French judicial history and argued that the trial was too unwieldy to continue. The packed hearing room had six large-screen televisions placed at even intervals to allow even those at the back to see, and judges frequently admonished spectators into silence.
Nathalie De Michel, who received the implants, said Wednesday she wanted Mas to acknowledge responsibility.
"We have the impression that he doesn't care. I want him at least to recognize that he made mistakes," she said.
Yves Haddad, Mas' lawyer, said his client was prepared: "He was ready to be here and to answer questions, and thinking about those who joined the case, even if it seems odd to some."
A former employee, who attended the trial Wednesday but asked not to be named because of the criminal allegations, said those who worked at the plant were told not to ask too many questions, even when women complained directly about medical problems. The employee said he suffered lung problems he blamed on years of handling unknown chemicals.
As investigators began uncovering the fraud, he said workers at the plant grabbed tubs of toxic materials and dumped them into the sewers to avoid detection.
A lawyer for TUV Rheinland, the Germany company that cleared PIP for certification, said its inspectors were also victims of a company-wide deception.
"The bad gel was taken away in trucks, the computer system was scrubbed of all references to it. Every employee lied. All the documentation was falsified," said Olivier Gutkes, a lawyer for TUV.
Mas declined comment as he entered the city's convention center ? which was turned into a courthouse to host all those participating in the trial. He has said he never intended harm and his lawyers said the company's failure ruined him financially ? a claim that drew angry murmurs from the crowd on Wednesday.
The vast majority of the implants were for cosmetic reasons. The rest were for breast reconstruction, often following cancer surgery. Within France, about a quarter of the implants malfunctioned, most by rupturing and leaking silicone, according to a government tally released earlier this month.
Doctors and scientists who have followed the case say medical complications stemming from the ruptures and leaks appear to be limited even when the implants rupture: rashes and localized pain were the most common complaints. But lawyers for the women say the full effects will not be known for years to come.
Nathalie Lozano, a Colombian lawyer who said she represents 1,500 women, said she came to Marseille to seek justice for clients she says lack the resources to pay for follow-up care.
"I could name very difficult cases of women who don't even have means to undergo exams and know what state their implants are in," she said. "They know that they are dangerous implants and nevertheless they don't even have a way to know if their implants are broken inside their body."
The implants in question were not sold in the U.S., where concerns about silicone gel implants overall led to a 14-year ban on their use. Silicone implants were brought back to the market in 2006 after research ruled out cancer, lupus and some other concerns, but the FDA still cautions that implants of any kind can rupture or cause other problems.
PIP ultimately went out of business, and regulators across Europe began demanding calls for tighter oversight of medical devices.
According to various government estimates, over 42,000 women in Britain received the implants, more than 30,000 in France, 25,000 in Brazil and 15,000 in Colombia. Venezuela, where PIP implants were hugely popular, offered free removals for the estimated 16,000 women with the implants, as did France.
Mas, his deputy Claude Couty, the quality director Hannelore Font, technical director Loic Gossart, and products chief Thierry Brinon face the possibility of five years in prison if convicted.
France has no system of class-action lawsuits, but people who feel they are victims can join criminal cases. Many of the women from abroad said they hoped a French decision in their favor would ultimately help them at home.
But that could prove more difficult because PIP is bankrupt, said Deborah Hensler, a Stanford University law professor who specializes in mass litigation.
"No lawyer would be willing to take on a case where she knows that in the end there's no way for the plaintiffs to recover," Hensler said.
Among the French women at Wednesday's trial, there seemed to be little expectation of reward.
"Women have lost their jobs because of him, their health because of him," said Joelle Manighetti, a French woman who received the implants after breast cancer surgery and blogs about her experiences. "With the way he has treated us from the beginning, I'm not expecting much from him."
___
Associated Press writer Libardo Cardona contributed from Bogota, Colombia.
___
Follow Lori Hinnant at https://twitter.com/lhinnant
Source: http://news.yahoo.com/french-execs-accused-breast-implant-swindle-182717252--finance.html
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Tuesday, April 16, 2013
Titan supercomputer to be loaded with 'world's fastest' storage system
If you figured Titan's title of the world's most powerful supercomputer would give the folks at Oakridge National Laboratory reason to rest on their laurels, you'd be mistaken. The computer is set to have its fleet of 18,688 NVIDIA K20 GPUs and equal number of AMD Opteron processors paired with what's said to be the planet's speediest storage system, making its file setup six times faster and giving it three times more capacity. Dubbed Spider II, the new hardware will endow the number cruncher with a peak performance of 1.4 terabytes a second and 40 petabytes of storage spread across 20,000 disk drives. Behind the refresh are 36 of Datadirect Networks' SFA12K-40 systems, which each pack 1.12PB of capacity. For more on the herculean rig's upgrade, hit the jump for the press release.
Filed under: Misc, Storage, Science
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Sunday, April 14, 2013
Mount Sinai study identifies new gene variations associated with heart rate
![[ Back to EurekAlert! ]](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uif5xZWXwLF1ZHquXlK6kXZBpsSnoo8Jq42cRvOYEDdDAZtWTHCt2Fq7HyW6UXu5Ib_oogY2uNGAvKhHgpyQ0lEutf0mhXUAZO-mYdUiE=s0-d){kind=small}
Public release date: 14-Apr-2013[ | E-mail |
Share ] Contact: Renatt Brodsky
Renatt.Brodsky@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Findings pinpoint 14 genetic targets in humans that may provide insight for the treatment of cardiovascular disease
(New York, NY April 14, 2013) Through a collaborative genome-wide study on individuals, researchers have discovered 14 new genetic variations that are associated with heart rate. Since heart rate is a marker of cardiovascular health, these findings could provide a better understanding of genetic regulation of heart beat and is a first step towards identifying targets for new drugs to treat cardiovascular disease.
The study, titled, "Identification of Heart Rate-Associated Loci and Their Effects on Cardiac Conduction and Rhythm Disorders," was published online this week in the April issue of Nature Genetics. Led by researchers at the Icahn School of Medicine at Mount Sinai and the Medical Research Council Epidemiology Unit in Cambridge, UK, the collaboration involved 268 researchers from 211 institutions, as well as six large research consortia joined forces.
In order to gain new insights into the genetic regulation of heart rate, Dr. Ruth Loos, Director of the Genetics of Obesity and Related Metabolic Traits Program at the Charles Bronfman Institute for Personalized Medicine at Mount Sinai and honorary investigator at the Medical Research Council Epidemiology Unit and her team, spent three years working on a genome-wide association study using data from 181,171 participants from 65 studies during 2009-2012. "Without any prior hypothesis, we studied the entire human genome hoping to identify new genetic variations that no one before had even imagined would play a role in the regulation of heart rate," said Dr. Loos, senior author of the study. "This discovery is just the beginning of something new and exciting and can hopefully be used to identify new drugs that can be used for the treatment of heart rhythm disorders."
In a follow-up study, experimental down-regulation of gene expression was then conducted on fruit flies and zebra fish, to better understand how genetic variations might affect heart rate. These experiments identified 20 genes with a role in heart rate regulation, signal transmission, embryonic development of the heart, as well as cardiac disorders, such as dilated cardiomyopathy, congenital heart failure and sudden heart failure. "Our findings in humans as well as in fruit flies and zebrafish provide new insights into mechanisms that regulate heart rate," said Dr. Marcel den Hoed, post-doctoral fellow at the Medical Research Council Epidemiology Unit and lead author of the study.
The follow-up study also showed that a genetic susceptibility for higher heart rate is associated with altered cardiac conduction and a reduced risk of sick sinus syndrome, a common indicator for pacemaker implantation. "Our study tripled the number of genetic variations that are known to be associated with heart rate, some of which are also associated with other cardiovascular risk factors and with heart rhythm disorder," said Dr. Loos.
###
About The Charles Bronfman Institute for Personalized Medicine
The Charles Bronfman Institute for Personalized Medicine (IPM) drives innovation in the data-driven and gene-based individualization of healthcare. The Institute's groundbreaking work led to the creation of the BioMeBiobank Program to enable innovation in personalized healthcare. Over 23,000 Mount Sinai patients have enrolled in the BioMe program, which helps them receive more targeted, personalized care in real-time based on their own DNA through Mount Sinai's electronic medical record (EMR) system. The EMR-linked personalized medicine system empowers participating BioMe patients by providing tailored information in data-driven, gene-based personalized healthcare. This information includes each enrolled patient's unique genetic information and clinical data.
Mount Sinai patients who enroll in the BioMe program also contribute to medical breakthroughs by consenting to make their DNA, genetic and clinical information available for medical research in a secure and de-identified manner.
IPM also provides participating healthcare professionals with education, tools and resources for up-to-date practice guidelines incorporating the latest gene-based information for personalized healthcare.
For more information, visit http://icahn.mssm.edu/research/institutes/institute-for-personalized-medicine
About The Mount Sinai Medical Center
The Mount Sinai Medical Center encompasses both The Mount Sinai Hospital and Icahn School of Medicine at Mount Sinai. Established in 1968, the Icahn School of Medicine at Mount Sinai is one of the leading medical schools in the United States. The Icahn School of Medicine is noted for innovation in education, biomedical research, clinical care delivery, and local and global community service. It has more than 3,400 faculty members in 32 departments and 14 research institutes, and ranks among the top 20 medical schools both in National Institutes of Health (NIH) funding and by U.S. News & World Report.
The Mount Sinai Hospital, founded in 1852, is a 1,171-bed tertiary- and quaternary-care teaching facility and one of the nation's oldest, largest and most-respected voluntary hospitals. In 2012, U.S. News & World Report ranked The Mount Sinai Hospital 14th on its elite Honor Roll of the nation's top hospitals based on reputation, safety, and other patient-care factors. Mount Sinai is one of just 12 integrated academic medical centers whose medical school ranks among the top 20 in NIH funding and by U.S. News & World Report and whose hospital is on the U.S. News & World Report Honor Roll. Nearly 60,000 people were treated at Mount Sinai as inpatients last year, and approximately 560,000 outpatient visits took place.
For more information, visit http://www.mountsinai.org/.
Find Mount Sinai on:
Facebook: http://www.facebook.com/mountsinainyc
Twitter @mountsinainyc
YouTube: http://www.youtube.com/mountsinainy
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 14-Apr-2013[ | E-mail |
Share ] Contact: Renatt Brodsky
Renatt.Brodsky@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Findings pinpoint 14 genetic targets in humans that may provide insight for the treatment of cardiovascular disease
(New York, NY April 14, 2013) Through a collaborative genome-wide study on individuals, researchers have discovered 14 new genetic variations that are associated with heart rate. Since heart rate is a marker of cardiovascular health, these findings could provide a better understanding of genetic regulation of heart beat and is a first step towards identifying targets for new drugs to treat cardiovascular disease.
The study, titled, "Identification of Heart Rate-Associated Loci and Their Effects on Cardiac Conduction and Rhythm Disorders," was published online this week in the April issue of Nature Genetics. Led by researchers at the Icahn School of Medicine at Mount Sinai and the Medical Research Council Epidemiology Unit in Cambridge, UK, the collaboration involved 268 researchers from 211 institutions, as well as six large research consortia joined forces.
In order to gain new insights into the genetic regulation of heart rate, Dr. Ruth Loos, Director of the Genetics of Obesity and Related Metabolic Traits Program at the Charles Bronfman Institute for Personalized Medicine at Mount Sinai and honorary investigator at the Medical Research Council Epidemiology Unit and her team, spent three years working on a genome-wide association study using data from 181,171 participants from 65 studies during 2009-2012. "Without any prior hypothesis, we studied the entire human genome hoping to identify new genetic variations that no one before had even imagined would play a role in the regulation of heart rate," said Dr. Loos, senior author of the study. "This discovery is just the beginning of something new and exciting and can hopefully be used to identify new drugs that can be used for the treatment of heart rhythm disorders."
In a follow-up study, experimental down-regulation of gene expression was then conducted on fruit flies and zebra fish, to better understand how genetic variations might affect heart rate. These experiments identified 20 genes with a role in heart rate regulation, signal transmission, embryonic development of the heart, as well as cardiac disorders, such as dilated cardiomyopathy, congenital heart failure and sudden heart failure. "Our findings in humans as well as in fruit flies and zebrafish provide new insights into mechanisms that regulate heart rate," said Dr. Marcel den Hoed, post-doctoral fellow at the Medical Research Council Epidemiology Unit and lead author of the study.
The follow-up study also showed that a genetic susceptibility for higher heart rate is associated with altered cardiac conduction and a reduced risk of sick sinus syndrome, a common indicator for pacemaker implantation. "Our study tripled the number of genetic variations that are known to be associated with heart rate, some of which are also associated with other cardiovascular risk factors and with heart rhythm disorder," said Dr. Loos.
###
About The Charles Bronfman Institute for Personalized Medicine
The Charles Bronfman Institute for Personalized Medicine (IPM) drives innovation in the data-driven and gene-based individualization of healthcare. The Institute's groundbreaking work led to the creation of the BioMeBiobank Program to enable innovation in personalized healthcare. Over 23,000 Mount Sinai patients have enrolled in the BioMe program, which helps them receive more targeted, personalized care in real-time based on their own DNA through Mount Sinai's electronic medical record (EMR) system. The EMR-linked personalized medicine system empowers participating BioMe patients by providing tailored information in data-driven, gene-based personalized healthcare. This information includes each enrolled patient's unique genetic information and clinical data.
Mount Sinai patients who enroll in the BioMe program also contribute to medical breakthroughs by consenting to make their DNA, genetic and clinical information available for medical research in a secure and de-identified manner.
IPM also provides participating healthcare professionals with education, tools and resources for up-to-date practice guidelines incorporating the latest gene-based information for personalized healthcare.
For more information, visit http://icahn.mssm.edu/research/institutes/institute-for-personalized-medicine
About The Mount Sinai Medical Center
The Mount Sinai Medical Center encompasses both The Mount Sinai Hospital and Icahn School of Medicine at Mount Sinai. Established in 1968, the Icahn School of Medicine at Mount Sinai is one of the leading medical schools in the United States. The Icahn School of Medicine is noted for innovation in education, biomedical research, clinical care delivery, and local and global community service. It has more than 3,400 faculty members in 32 departments and 14 research institutes, and ranks among the top 20 medical schools both in National Institutes of Health (NIH) funding and by U.S. News & World Report.
The Mount Sinai Hospital, founded in 1852, is a 1,171-bed tertiary- and quaternary-care teaching facility and one of the nation's oldest, largest and most-respected voluntary hospitals. In 2012, U.S. News & World Report ranked The Mount Sinai Hospital 14th on its elite Honor Roll of the nation's top hospitals based on reputation, safety, and other patient-care factors. Mount Sinai is one of just 12 integrated academic medical centers whose medical school ranks among the top 20 in NIH funding and by U.S. News & World Report and whose hospital is on the U.S. News & World Report Honor Roll. Nearly 60,000 people were treated at Mount Sinai as inpatients last year, and approximately 560,000 outpatient visits took place.
For more information, visit http://www.mountsinai.org/.
Find Mount Sinai on:
Facebook: http://www.facebook.com/mountsinainyc
Twitter @mountsinainyc
YouTube: http://www.youtube.com/mountsinainy
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-04/tmsh-mss041113.php
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reflective roof, white roof painting (Home Roofing)
There are some great roof coatings available that are actually energy star
Qualified. However as for most roof paint applications, proper preparation is required to acheive
Long lasting results. Often time proper preparation is not implemented and may result in less than satisfactory
Long term results. Properly prepared to include cleaning, sealing imperfections, vents, corners etc and priming before paint is applied. Using a high quality elastomeric, ceramic, or rubberized sealers are best.
Source:?Absolute Home Solutions
Source: http://answers.angieslist.com/reflective-roof-white-roof-painting-q43015.aspx
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Saturday, April 13, 2013
Misconceptions About Network Marketing, and Why This Is A Good ...
Posted on 12. Apr, 2013 by Viola Tam in MLM BLOG, MLM Success Mindset
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I have been talking about a number of misconceptions in network marketing and this time I?m going to cover one which is a very interesting one. ?
In many people?s mind, network marketing is about chasing their friends and relatives. ??Oh, I don?t want to do that!? The thought of being in this Network Marketing chasing gang can be daunting for a stay-at-home mum!
What if you can do network marketing professionally? You don?t have to chase your friends and relatives.
How are we going to promote products, services or business opportunity if we are not chasing them? Simple, ?we just help them!
One of my favourite trainers Tom ?Big Al? Schreiter joked about that the mission of all professional network marketers is to promote World Peace.
When people are keen to know what you have to offer, you share. That?s it. And if people are not open to new ideas, not open to checking out what you have to offer, leave them alone.
This is a common question for ?serious network marketers. If I?m not chasing my friends and relatives, where can I find people to talk to??
A lot of people do network marketing by initially talking to their friends and relatives. This is mainly they know that the products and services can help them. Or, they believe that by promoting great products or services, they can bless their friends or relatives with an additional source of income. However, network marketing is not for everyone. Most people can only enrol just a few of their friends.?
Asking for referrals is a very effective?way of getting the network marketing business going. Yet, some people are actually loving the product so much that they would like to promote it. That is, they themselves goes into the business. ?They are to build their own business. They are not going to refer people to you. In that case, ?you will have to continue networking. ?This is what most mums can do well.
When done professionally, you continue to enrol others or get referrals from others who may know some other people who need the products or opportunity.
There is also one other newer breed of network marketing called ?attraction marketing?. Marketing is primarily done online. The whole online community knows what you are doing. If people are looking for opportunities or looking for products and services, they will resonate with what you have to offer. They will contact you. This is a whole new different dynamic. You definitely do not need to chase your friends and relatives if you decide to do network marketing that way!
If you ?would like to explore a little bit about this online attraction marketing, send me an email or leave a comment below. ?I?ll be more than happy to help you along this journey.?
PS:?While online attraction marketing is making a lot of buzz, attraction marketing can also be practised offline. How? Simply by doing network marketing professionally. Others will be attracted to you because of your professionalism.?
You can probably appreciate that chasing friends and relatives may not be the smartest move. I hope my blog post can be the wake up call for network marketers who are still chasing others like crazy!
I?d love to hear your thoughts on this topic! Do leave a comment. Thanks!
Source: http://violatam.com/mlm-blog/misconceptions-about-network-marketing-good-home-business-mums/
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